Biomaterials
Research Department
General People General
Lab. In-vitro Lab. In-vivo Lab. Current Projects Completed
Projects
General
Information:
The biomaterials
research department is a leading group in biomaterials in Iran. The main
present fields of research at biomaterial department are focused on
morphological studies of the polymer surfaces, analysis of polymer blends and
copolymers as well as polymeric biomaterials design and manufacturing.
Laser induced surface modification of polymers to improve biocompatibility is
one of the main current activities in this department.
Our main research activities includes biocompatibility evaluation of polymeric
biomaterials using in-vivo and in-vitro assays via implantation and cell
culture techniques and applying FT-IR, ATR-FT-IR, UV-visible laser beam, X-ray
diffraction measurements, electron spectroscopy for chemical analysis (ESCA),
scanning electron microscopy (SEM), energy dispersive X-ray analysis and
dynamic mechanical thermal analysis (DMTA), and electro kinetic analyzer (EKA)
for zeta potential measurement, and surface tensiometry to characterize the
bulk and surface properties of the biomaterials.
The other activities are development of novel techniques for creating blood
compatible materials as well as laser-induced copolymerization of acrylated
monomers onto the surface of polymers to achieve the new biomaterials
generation. Also designing a special artificial skin using polymers and laser
beam and, a biopolymer-biomaterial adhesive for prevention of the blood oozing
are the two recent achievements at biomaterial department.
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1. Mirzadeh, Hamid (Ph.D.);
Head of IPPI
2.
Khorasani, Mohammad
Taghi (Ph.D.); Head of Department
3.
Shamshiri, Morteza
(DVM-MPH-VPH)
4.
Arabi, Hassan
(Ph.D.)
5. Amanpour, Saeid (DVM-Ph.D.)
6. Barzin, Jalal ,
(M.Sc.)
7. Daliri, Morteza (Ph.D.)
8. Fallahi, Delaram (M.Sc.)
9. Mohammadi, yosef (M.Sc.)
10. Sadatnia, Behrouz (M.Sc.)
11. Yaghobi, Nakisa (M.Sc.)
12 .Zandi, Mojgan (M.Sc.)
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Laboratories:
I. General Lab.
The main activities of this
laboratory include synthesis of novel biomaterials, processing, prototyping
and modification of bulk and surface properties
by chemicals,
radiation and analysing and determination of these products. Meanwhile, in
collaboration with different universities, research centers and industries,
joint projects or post-graduate dissertation researches are currently
performed.
Facilities:
1- Contact angle measuring
system G10:
This instrument is a
flexible measuring instrument for the determination of contact angles for a
wide range of samples. The contact angle of a sessile drop on a solid surface
is measured.
Features
· Measurement of contact angles of single
drops of test liquids on a solid surface.
· Measurement of advancing and receding
contact angles by volume control of sample drop.
· Determination of the surface free
energy of solid samples with several calculation methods.
· Determination of surface and
interfacial tension of liquids with the drop shape analysis (pendent drop
method).
2- Processor tensiometer
K12:
Features
· Surface and interfacial tension
measurement of liquids by the ring and plate methods.
· Online contact angle measurement by the
Wilhelmy plate method as well as the determination of sorption and the wetted
length.
· Determination of the critical micelle
(formation) concentration.
· Surface energy determination.
· Sedimentation of suspensions and
penetration into already sedimented solids measurements.
· Determination of the density of
liquids.
3- Contalab
computer-controlled laboratory reactor:
This is a reactor for
daily use in chemical research and development laboratories as well as pure
biomaterial preparing.
The following basic operations are available:
· Internal temperature control
· Jacket temperature control
· Heat to boiling point, time dependent
addition, temperature dependent addition, change pH during reaction, vacuum or
purging inert gas control during reaction.
4- Friction measuring
apparatus:
This apparatus
determines the coefficients of static and kinetic friction of plastic films,
paper and similar materials by measuring the force required to draw a moving
sled over a stationary horizontal plane at a prescribed constant speed. It is
designed to conform with BS 2782 method 311A, ASTM D1894-78, DIN 53 375 and
other international standards.
5- Surface and volume
resistivity apparatus:
This apparatus
determines the electrical volume and surface resistivity of vulcanized rubbers
and plastics. The resistivity is measured from the current flowing through the
material when a voltage is applied between two electrodes on the surface or
opposite faces of a sheet. It is designed to conform with BS 230A and 231A.
6- Electro Kinetic Analyzer
(EKA):
The EKA operates according to
the principles of streaming potential and streaming current. An electrolyte
solution flows through the measuring cell containing the sample to be measured.
Depending on the flow resistance of the sample (capillary bundle) a pressure
drop is detected across the measuring cell. The measured values of Δp
(pressure drop across the cell) and ΔU (voltage difference) serve to
determine the zeta potential.
7- Plasma instrument:
Emitech solid state system is
a tabletop plasma chemistry reactor designed to provide the scientific,
educational and microelectronic community with plasma technology. All controls
are automatic. The plasma process is accomplished through the use of a low
pressure, RF induced gaseous discharge.
8- Mixing mill:
The open two-roll mill
for rubber mixing and blending of base materials for production of biomaterial
samples.
9- Extruder:
The rubber extruder
has been designed for self feeding and more effective mixing in the
manufacturing process of biomaterial products such as blood shunt.
10- Molding Press:
This instrument is
used for production of biomaterial components such as silicone O-ring and so
on.
11- Laser instruments:
There are 7 lines of
laser beams in the range of infrared, visible and ultraviolet, which have been
used as excitation source for polymer surface treatments.
These instruments belong to Laser Research Center of Iran and are used by the
Biomaterials Department of IPI.
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II. In-vitro Lab.
This is a well equipped
laboratory under clean air condition and sterile zone for cell and tissue
culture methods and invitro testing of biomaterials (e.g. natural or synthetic
polymeric biomaterials) produced in Iran Polymer Institute. All polymeric biomaterials
for medical applications are testing in this laboratory, including cell culture
cytotoxicity, cell culture and blood compatibility, sterility, safety and etc.
Different cells and cell
culture media, reagents, supplemented materials, flasks and other facilities
are available for using in different methods of cell culture. Daily watching,
reculturing and passage keep the cells at appropriate condition and freezing
the cells for keeping at -196 °C in liquid nitrogen. Laminar airflow, top bench
centrifuge, inverted microscope, CO2 incubator, autoclave, oven and
sterile filtration system are available in this laboratory. Tissue engineering
method is the current topic research project of the lab.
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III. In-vivo Lab.
Polymers that are candidate
for implantation in animals are tested on laboratory animals (rodents, rabbit,
sheep and others) to study the polymer and body interactions. Surgical
facilities and animal care rooms are available in this lab.
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1. Design and Production of Heart's Pericardium Membrane
2. Design and Production of a Blood Compatible Polymeric
Biomaterial Blend
3. Design and Production of Artificial Cartilage
4. Design and Production of Artificial Vascular Grafts
5. Design and Production of Medical Adhesive to Stop Severe
Bleeding
6. Field of Tissue Engineering for Tissue Regeneration Using
Different Polymers
7. Grafting of Hydrogels on Polymers by Laser for Biocompatibility
and Blood Compatibility
8. Peptide Immobilization onto Laser-Irradiated Polymer Films to
Improve Blood Compatibility
9. Preparation of Chitin and Chitosan from Persian Gulf Shrimp's
Shell
10. Production of Tubules for Blood Dialysis Equipment
11. Production of Wound Dressings
12. Pyrocarbon Pilot Plant for Medical Purposes
13. Production of heart valve
14. production of blood warmer
15. Zeta potential measurement of grafted polyurethane as blood
compatibility factor.
16. Production of polyhydroxy alkanoates from
microorganisms.
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1. Blood Compatibility Evaluation of PAAm-PDMS Blend and the Laser
Grafted PAAm onto PDMS Surface
2. Characterisation, Formulation and Mould Design for Production of
Insulin Injector
3. CO2 - Pulsed Laser Induced Surface Grafting of
Acrylic Acid on Ethylene Propylene Rubber as Surface Hydrophilic Materials
4. Development of Composition for Polymer Cryoaccumulators for
Thermostable Conditions of Storing and Transporting of Medico-biological
Objects
5. Development of Composition for Soft Polymer Cryoaccumulators for
Surgery Applications
6. In-Vivo Study of Acrylate Grafted PDMS of Skin Application
7. Laser Grafting of EPR as Biomaterials
8. Laser Grafting of PET as Biocompatible Materials
9. Producing Microcapsules that Contain Essence of Orange and
Evaluating Some Parameters that Affect it
10. Study, Mould Design and Production of Silicone O-Ring for
Sealing of Dialyser Filter
11. Surface Modification of PDMS by CO2 - Pulsed Laser
for Biomaterial Uses
12. Synthesis, Characterisation and Release Studies of Polymers
Containing Pendawt Pesticides
13. UHMWPE and Silicone Rubber Composite as a shock Absorber Cup of
the Hip Prosthesis, Manufacturing and Characterisation
14. Design and Production of Blood Dialysis O-Ring Filter
15. Design and Production of Cryogenic Hydrogels Used in Cold
Operational Surgeries and Maintaining the Fresh Cells and Tissues
16. Design and Production of Eye Valve for Glaucoma Treatment
17. Production of Insulin Syringe Stopper
18. Production of Solid Multipurpose Ultrasonic Coupler
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